The SABC reported Mbuli collapsed while watching a rugby match between the Cheetahs and the Reds at the Free State Stadium on Saturday night.
He was treated on the scene by paramedics, before being rushed to a nearby hospital where he died. Reports suggest cause of death was a heart attack.
Vuyo had been tweeting live updates from the game right up until he collapsed. His last tweet at 9pm read, “8 mins gone in 2nd half. 21 – 6 Cheetahs lead.”
He had celebrated his 46th birthday just days ago on May 14.
Known for his trademark sign-off, "Sharp. Sharp.", Vuyo made his television debut in 1993 on TSS (now SABC 3) as a continuity presenter. In his 20 years at the national broadcaster, he interviewed a wide range of celebrities, politicians and newsmakers from around the world. In a 2012 interview with the Sowetan, he joked his dream was to interview supermodel Naomi Campbell.
“I think Naomi would make an interesting interviewee,” he said. “She has a big temper – that interests me.”
In 2011, Vuyo split from his wife of 16 years, Savita. They had two children together, Siphosihle (15) and Sithenkosi (13).
Sources: SABC, Sowetan, Twitter